The emergence of the inflammatory infiltrate in the Dermis.
Speaking of chronic character, it must be emphasized that, if a young man is a tiny Plaque appeared and soon disappeared, which means that in 20 years he can look back on new tiles.
Psoriasis "slumbers", but not cured, and his behavior is reminiscent of the man who cured many years ago from alcoholism, but, for obvious reasons, avoid any alcohol because after 30 years of sobriety you get in the fight.
Causes of psoriasis
The incidence of Psoriasis is very high: even in the successful countries of Western Europe, he meets 2% of the population. To start, the disease may at any age, but the debut often occurs at a young age, and only in 1/3 of patients it occurs after 40 years.
It is believed that the presence of relatives with Psoriasis significantly increases the risk of its occurrence, and there is an autosomal – dominant mode of transmission of the genetic defect (i.e., not grounded). But most of the time the causes of Psoriasis are the effects of a number of negative factors that contribute to the restructuring of the body.
We list the most important causes of psoriasis:
Chronic Stress, Stress, adverse social climate;
Microbial and viral infections, prone to chronic course (e.g., steptokokkovaya infection );
Direct physical action on the skin (excessive friction, pressure, frequent exposure to the sun);
Injuries to the skin.
The hormonal imbalance. Often the Psoriasis occurs when occurs in the pubertal period, and least in the change of years. This is related to the influence of the thyroid gland and the hormones of a bark of adrenal glands;
The intake of certain medications. This action was in the case of lithium salts, preparations in psychiatry, the Anti-Malaria agent chloroquine;
Alcohol, especially beer. Both the more severe course of the disease, and so elementary promotes its beginning;
Obesity, or being overweight. There are indisputable facts, which show that people who have led to your weight to normalcy after years of abundance, psoriasis almost gone and psoriatic Arthritis
Climatic Factors. Psoriasis runs in the coastal town, a warm, Sunny climate. And here is a continental, humid, and cold climate can contribute, such as the onset and progression of the disease;
HIV infection. This disease contributes to the emergence of various diseases, the "enjoyed" a defect of the immune system, and psoriasis is no exception.
What happens in the skin, or pathogenesis of Psoriasis
"Unit" Psoriasis is Plaque cutaneous, flows in Immune inflammatio, as well as in the joints in psoriaticheskom Arthritis.
In blayshkah many substances, such as analogues discovered leukotrienes, which is a hotbed of leukocytes inflammatio. As a result of the interaction of keratinocytes with immunokompetentnymi cells, a Zone inflammatio occurs, with the release of mediators of inflammatio.
In psoriaticheskih blayshkah, and in the synovial fluid in psoriaticheskom Arthritis presence of TNF-Alpha or Tumor necrosis factor. The Tumor itself has nothing to do with it — this is the title of historical. It is known that TNF plays an active role in various chronic inflammatio.
In the skin, various inflammatory changes, leading to the emergence of highly characteristic for the Psoriasis characteristics: spots, Terminal triad-foil, and a bloody dew.
In the light poskablivanii tiles (e.g., with the finger nail), the characteristic Chipping and flaking of dandruff.;
Under certain conditions (e.g. after the shower, on the already dry skin) and lift to remove the edge of the shed, and take it in the Form of grey – yellow, like parchment, thin Film, sometimes up to 3-4 cm, the Symptom of the terminal foil;
If in the place of the removed film poskoblit, the appearance of droplets of blood, similar to that of the Tau, which is called blood.
This can lead to the skin and the itching in the night, the Patient stryahivaet with bed sheets, a mass of dead scales, a mixture of flour with bran, sharps ,and blades can be reminded to be droplets of blood. These symptoms are typical for acute stage.
Psoriasis — the first Phase, photo
In the case of the Psoriasis Plaques of all of the layers of the skin. In the case of Psoriasis, the initial phase of the Plaque to the entire development, is no different, according to their main characteristics of the traditional tiles, but at the beginning of the following characteristic properties:
it is formed on the surface of intact skin flat bumps, 1-3 mm in diameter;
its clear border;
Color – intense red or pink, sometimes cyanosis, especially in the case of Psoriasis on the legs;
the surface is loose, and formed by layering of the scales, the silvery-white hue;
Plaques merge, in consequence of large deflections.
With the phenomenon of Kebnera , or with fresh injuries to the skin often the psoriasis starts.
Where are the rashes?
Symptoms early stages of psoriasis it is noted in the "favorite places". These include:
The surface of the elbow and knee joints (sometimes – dorsal, this is called "inverse Psoriasis");
Volosennaya part of the head. You lift the hair, on the edge of the red bezel in the event of aggravation of the skin, light end projecting behind the line of the hair growth: "psoriaticheskuyu crown";
Psoriasis "loves" поселяться behind the ears, in addition to the growth of hair, and in the interior of the ear cups;
Somewhat less frequently affects the major skin folds.
In some cases, the development of Plaques promotes a strong itching. It is often, along with the redness of the skin on the periphery talks about the advanced stages of Psoriasis, if there are new scales.
Psoriasis on the nails of the hands and feet + photo
Finger nails in the treatment of psoriasis, affects almost 50% of the patients. To you holes and spots appear.
Their free edge is growing poorly, it is yellowish , the suspicion of a fungal infection. Even the body of the nail changes color, it seems as if transparent areas, the the title of "fat".
The most common nail infections States that in the case of a patient with a Psoriasis-Arthritis, or a tendency to its development.
The Psoriasis is not all nails, but only on the feet or hands. And even then, if it is Arthritis Finger, then the nail will not be joints on the Hand, be astonished exactly where rigid. Small fingers can be affected and hurt index finger. Direct communication is not.
Stages of Psoriasis exacerbation, stability, and Regression
All the worries and grief, falls on the progression of the disease, when the symptoms escalated. For each patient, an exacerbation bears an individual character. Sometimes aggravation occurs in response to the "good deeds".
For example, a Patient smoked for several years. The decision that Smoking is a detrimental effect on the course of Psoriasis (and rightly so), he throws it, but after a month added to 5-8 kg. per a result of a significant aggravation to the increase in the weight and "ignored" the fact that a successful fight against Smoking.
In spite of the "special way", there are some common signs:
Aggravation appears after a cold, sore throat, Stress, Binge;
The emergence of new patches occurs;
On old stains extended peripheral area, patch "to grow";
Thickens the layer of scales;
Enhanced itching of the skin. In the room where lives the Patient with Psoriasis, better laminate, and Linoleum, as they skin less noticeable dandruff, the itching in large quantities to Plaques;
In severe forms the reinforcement of the joint pain, General appears to be uncomfortable occurs;
For the advanced stages of the typical phenomenon Kebnera. Any violation of the skin is transformed into a new tile.
Reducing the signs of worsening of the psoriatic Plaques is not altered, the particular itching occurs. "HUSK" with the patients a little spilled.
On blayshkah stops the growth, formed "psevdoartoficheskyi" bezel, the disappearance and re-aggravation.
Mostly the improvement starts with the middle of the plate. The disappearance of the shed, starts the new skin appears. The Zone of the peripheral growth continues to be pale and inactive, in consequence of the "garlands" of the rings, and all sorts of whimsical spots. If the rash is completely gone, often occurs at this point on the area of the skin with decreased pigmentation.
Very often step back psoriaticheskih rash develops in the summer, if the Patient happens in the sun. Deterioration, on the contrary, in spring and in autumn, when the skin suffers from a lack of sun.
In the case of the incomplete Regression of the lesions usually the "duty Plaques" that are in the area of the elbows and on the knees.
Types of Psoriasis, and in particular of the skin
In the case of the normal, the skin there are several types of Psoriasis: seborrheic, exudative Psoriasis of the skin folds as well as the palms of the hands and soles of the feet. Psoriasis of the nails do not usually occur individually.
Seborrheic Form is very similar to the eponymous Dermatitis. Scales are on the scalp, behind the ear, on the chest. Skin rashes are vague borders, you impregnated sebum and have an oily, thick and loose scales;
In exudative Psoriasis (the exudate is more common in obesity), the cuticle penetrates, a little bit of the symptoms changes. As a result, the shed silver undertone luster, lose glued on are yellow and resemble scabs;
In the case of Psoriasis of the palms and soles of the feet, the isolated more frequently in people who work physically (chronic Trauma), and sometimes rashes. Often, hyperkeratosis develops ;
Psoriasis of the skin folds, especially, developed a strong pathology, e.g. Diabetes mellitus. Plaques occur around the navel, the mammary glands, in the step, and in the inguinal folds.
Sometimes psoriaticheskie skin rashes on the genitals. In the case when the only sign of the disease and Psoriasis is on the body, then there are certain difficulties in the differential diagnosis of Psoriasis, and urogenital infections.
Severe forms of psoriasis
We get short with generalizovannimi forms of Psoriasis process psoriaticheskaya aritrodermiya , pustuleznyi psoriasis and Arthritis.
psoriaticheskaya aritrodermiya is nothing more than a Progressive stage of Psoriasis, exciting the entire skin.
The skin is hot, the temperature rises up to high numbers. Against the background of the General aritrodermii not distinguish the figure of the previous Psoriasis: everything merges in a joint inflammatio. This condition can provoke aletrolitnye disorders and heart failure.
In Pustuleznom psoriasis is characteristic to the formation of pustules, or ulcers.
These ulcers can be sterile and consist of neutrophils, but then get infected. Over the course of the disease is also severe, with the features inflammatio, burning and pain on the skin, the General reaction, the change in the blood, increased erythrocyte sedimentation rate. Pustules coalesce and purulent "lake". The pustules are in different stages of development, and can develop severe complications (kidney and heart).
Psoriatic Arthritis pain, mostly in the hands and feet.
Sometimes pandaktilit – Finger inflammatio, reminiscent of the "sausage", the skin has a bluish tint.
In General, the skin damage will occur first, and then affects the joints. Also affects the joints, spine, and temporomandibular joint.
Involvement of the joints of the axial skeleton speaks of a negative course of the disease. In severe cases, the End is destroyed-phalanges completely and mutiliruyushaya Form of psoriasis.
Treatment of Psoriasis — medications, ointments, and methods of therapy
It is not certain that a complete cure of psoriasis is possible, and generic medications for the psoriasis. But to achieve you life long Remission, normal health, and complete absence of Plaques.